Tissue Lysates
Cayman Chemical ThyroId Hormon Receptr nta 1mg
An orally active selective inhibitor of Cdk4 (IC50 11 nM) and Cdk6 (IC50 16 nM) with antiproliferative activity against retinoblastoma-positive tumor cells blocking retinoblastoma phosphorylation and inducing G1 arrest used to demonstrate a role for insulin-activated cyclin D1-Cdk4 signaling in the control of glucose metabolism
Cayman Chemical ThyroId Hormon Receptr nta 5mg
An orally active selective inhibitor of Cdk4 (IC50 11 nM) and Cdk6 (IC50 16 nM) with antiproliferative activity against retinoblastoma-positive tumor cells blocking retinoblastoma phosphorylation and inducing G1 arrest used to demonstrate a role for insulin-activated cyclin D1-Cdk4 signaling in the control of glucose metabolism
Cayman Chemical ProcynIdIn B4 1mg
A dual inhibitor of FTase and GGTase I (IC50s 2 and 98 nM respectively) inhibits prenylation of FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s 92 and 6760 nM respectively) inhibits prenylation of the oncogenic protein Ki-Ras in PSN-1 cells in a concentration-dependent manner reduces HDJ2 and Rap1a prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day has no effect on Ki-Ras prenylation in patient-derived PBMCs inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s 6 48 and 84 1 M respectively) inhibits IL-2-induced proliferation of CTLL2 cells (IC50 0 81 M)
Cayman Chemical 17 R-ResolvIn D1-d5 100ug
An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7 5 UM
Cayman Chemical Programmed Cell Death Protein
A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC50 127 nM in CD34 cells) induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC50 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft immunodeficient mice
Cayman Chemical 11-dehydro Thromboxn B3 100ug
A potential inhibitor of NEP an enzyme responsible for the metabolic inactivation of enkephalins expected to induce natriuretic and diuretic effects
Cayman Chemical HOPSTI1 PolycLNal ntIbod 100ug
An inhibitor of the plasmin activating enzymes streptokinase fibrinokinase and urokinase (IC50s ~8 M for all in an enzyme assay) selective for plasmin activating enzymes over trypsin (IC50 500 M) inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner reduces ex vivo fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg
Cayman Chemical JasplakInolIde 100ug
An nternal standard for the quantfcaton of N-butyryl-L-homoserne lactone by GC- or LC-MS